Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination

Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination

Blog Article

Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses.We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil.As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part return of the BCG vaccination to reduce the impact of COVID-19 in healthcare MENOSMART PLUS workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines.Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination.

Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.